Design and evaluation of new quinazolin-4(3H)-one derived PqsR antagonists as quorum sensing quenchers in Pseudomonas aeruginosa
Description
A study focused on the design, synthesis and evaluation of pqs quorum sensing inhibitors
External URI
Related publication DOI
Subjects
- Pseudomonas aeruginosa
- Biofilms
- Quorum sensing (Microbiology)
- Pseudomonas aeruginosa, PqsR, Pseudomonas quinolone signal, PQS, biofilms, quorum sensing inhibition
- Biological Sciences::Microbiology::Bacteriology
- Q Science::QR Microbiology
Divisions
- University of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Life Sciences
Research institutes and centres
- University of Nottingham, UK Campus
Deposit date
2022-04-22Data type
Crystallography files, Data analysis from reporter strain, imaging, and pyocyanin and LCMSMS analysisContributors
- Mashabi, Alaa
- Richardson, William
- Vico Oton, Eduard
- Romero, Manuel
- Robertson, Shaun
- Grossman, Scott
- Sou, Tomas
- Liu, Ruiling
- Halliday, Nigel
- Kukavica-Ibrulj, Irena
- Levesque, Roger
- Bergstrom, Christel
- Kellam, Barrie
- Emsley, Jonas
- Heeb, Stephan
- Williams, Paul
- Stocks, Michael
- Cámara, Miguel
Funders
- Biotechnology & biological Sciences Research Council
- Other
- JPIAMR
Grant number
- EP/N006615/1
- EP/K005138/1
- EP/N03371X/1
- N501852/1
Collection dates
- 2015/05 - 2020/12
Data collection method
Molecular Docking, Mass spectrometry, NMR, Isothermal Calorimetry, Bioreporter assay, Alkyl quinolone quantification, pyocyanin quantification, PqsR protein expression, Galleria Mellonella survival assay, Microscopy and biofilm formation assayResource languages
- en