Nigrosome depigmentation as seen on neuromelanin-sensitive MRI at 3T as diagnostic marker in clinical uncertain parkinsonism: analysis plan for the secondary aims of N3iPD study

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Publication date
2023-12-01
Creators
Xing, Yue
Auer, Dorothee
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Description
Access to these files may be requested. Please contact Dr Xing at You.Xing@nottingham.ac.uk. In our prospective multi-centre MRI study at 3T, our primary aim was to establish the prospective diagnostic value of iron-sensitive susceptibility-weighted MRI of the substantia nigra in clinical uncertain Parkinsonism. We predefined depigmentation measured by neuromelanin-sensitive MRI scans (Trial registration number NCT03022357) as a secondary aim. This document details the research questions, hypotheses and analysis plan related the neuromelanin-MRI.
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Subjects
  • Parkinson's disease -- Diagnosis
  • Brain – Imaging
  • Diagnostic imaging
  • Magnetic resonance imaging
  • Parkinson Disease -- diagnosis
  • Magnetic Resonance Imaging
  • Neuroimaging
  • Neuromelanin MRI, depigmentation, suspected Parkinsonism, clinical uncertain Parkinsonism, substantia nigra, multimodal MRI
  • Subjects Allied to Medicine::Anatomy, physiology & pathology::Neuroscience
  • Subjects Allied to Medicine::Medical technology::Radiology::Radiography, diagnostic
  • W Medicine and related subjects (NLM Classification)::WL Nervous system
Divisions
  • University of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Medicine
Deposit date
2023-12-01
Corporate creators
  • N3iPD team: Saadnah Naidu, Tayyib Hayat, Halim Abdul-Sapuan, Stefan Schwarz, Nin Bajaj, Jonathan Evans, Antonio Martin-Bastida, Marta Gennaro, Andreas-Antonios Roussakis, Paola Piccini, Jim Birchall, Rob Skelly
Data type
Protocol
Contributors
  • Stefan, Pszczolkowski
  • Chris, Tench
Funders
  • Other
  • Michael J. Fox Foundation
Grant number
  • 11473
Parent project
  • Trial registration number: NCT03022357
Data collection method
Data analysis plan
Resource languages
  • en
Publisher
The University of Nottingham
CC-BY-NC-ND
Except where otherwise noted, this item's license is described as Creative Commons by Attribution, Non Commercial, No Derivatives