Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation
dc.contributor.author | Alexander, Morgan | |
dc.contributor.other | Vassey, Matthew | |
dc.contributor.other | Figueredo, Grazziela | |
dc.contributor.other | Scurr, David | |
dc.contributor.other | Alexander, Morgan R | |
dc.contributor.other | Williams, Paul | |
dc.contributor.other | Luckett, Jeni C | |
dc.contributor.other | Ghaemmaghami, Amir | |
dc.contributor.other | Winkler, David A | |
dc.contributor.other | de Boer, Jan | |
dc.contributor.other | Beijer, Nick R. M. | |
dc.contributor.other | Vasilevich, Aliaksei S. | |
dc.contributor.other | Vermeulen, Steven | |
dc.contributor.other | Carlier, Aurelie | |
dc.date.accessioned | 2020-05-05T08:10:27Z | |
dc.date.available | 2020-05-05T08:10:27Z | |
dc.date.issued | 2020-05-05 | |
dc.identifier.uri | https://rdmc.nottingham.ac.uk/handle/internal/8310 | |
dc.description.abstract | Material topography is known to influence macrophage attachment and phenotype, providing opportunities for the rational design of ‘immune-instructive’ topographies to modulate macrophage function and thus foreign body responses to biomaterials. However, no generalisable understanding of the inter-relationship between topography and cell response exists. We therefore utilise a high throughput screening approach to investigate the relationship between topography and human monocyte-derived macrophage attachment and phenotype, using a diverse library of 2176 micropatterns generated by an algorithm. We use machine learning to successfully build a model that correlates cell attachment and phenotype with a selection of descriptors, illustrating that materials can potentially be designed to induce pro-inflammatory, anti-inflammatory or regulatory immune responses, for future application in the fight against foreign body rejection of medical devices. | en_UK |
dc.language.iso | en | en_UK |
dc.publisher | The University of Nottingham | en_UK |
dc.rights | CC-BY | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.lcsh | Macrophages | en_UK |
dc.subject.lcsh | Immune response -- regulation | en_UK |
dc.subject.lcsh | Biomedical materials | en_UK |
dc.subject.mesh | Biocompatible Materials | en_UK |
dc.subject.mesh | Immunomodulation | en_UK |
dc.subject.mesh | Immunologic Factors | en_UK |
dc.subject.mesh | Macrophages | en_UK |
dc.title | Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation | en_UK |
dc.identifier.doi | http://doi.org/10.17639/nott.7050 | |
dc.subject.free | biomaterials, high-throughput screening, immune-modulation, topography | en_UK |
dc.subject.jacs | Biological Sciences | en_UK |
dc.subject.lc | Q Science::QR Microbiology | en_UK |
dc.date.collection | 2018-2019 | en_UK |
uon.division | University of Nottingham, UK Campus::Faculty of Science::School of Pharmacy | en_UK |
uon.funder.controlled | Engineering & Physical Sciences Research Council | en_UK |
uon.datatype | Excel spreadsheets, GraphPad prism files, jpeg images, Notepad (readme) files | en_UK |
uon.grant | EP/N006615/1 | en_UK |
uon.collectionmethod | Microscopy, XPS, Tof-SIMS, ELISA, immunofluorescent staining | en_UK |
uon.institutes-centres | University of Nottingham, UK Campus | en_UK |
uon.preservation.rarelyaccessed | true | |
dc.relation.doi | 10.1002/advs.201903392 | en_UK |
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