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Immune-instructive polymers
(The University of Nottingham, 2020-05-01)
We identify polymers which instruct different immunological responses by modulating macrophage attachment and polarisation to pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotypes. These immune-instructive ...
Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation
(The University of Nottingham, 2020-05-05)
Material topography is known to influence macrophage attachment and phenotype, providing opportunities for the rational design of ‘immune-instructive’ topographies to modulate macrophage function and thus foreign body ...
Data for Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip
(The University of Nottingham, 2020-09-18)
Human mesenchymal stem cells (hMSCs) are widely represented in regenerative medicine clinical strategies due to their compatibility with autologous implantation. Effective bone regeneration involves crosstalk between ...
Single cell metabolic profiling of macrophages using 3D OrbiSIMS: correlations with phenotype
(The University of Nottingham, 2022-06-10)
ABSTRACT: Macrophages are important immune cells that respond to environmental cues acquiring a range of activation status represented by pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes at each end of their ...