Microparticles decorated with cell-instructive surface chemistries actively promote wound healing
dc.contributor.author | Ghaemmaghami, Amir | |
dc.contributor.author | Alexander, Morgan | |
dc.contributor.author | Irvine, Derek | |
dc.contributor.other | Latif, Arsalan | |
dc.contributor.other | Fisher, Leanne | |
dc.contributor.other | Dundas, Adam | |
dc.date.accessioned | 2022-11-18T09:07:18Z | |
dc.date.available | 2022-11-18T09:07:18Z | |
dc.date.issued | 2022-12-01 | |
dc.identifier.uri | https://rdmc.nottingham.ac.uk/handle/internal/9856 | |
dc.description.abstract | Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as in diabetic wounds, results in chronic non-healing wounds. Fibroblasts are a critical cell type involved in wound healing. We screened 315 different polymer surfaces to identify candidates which actively drove fibroblasts towards either pro- or anti-proliferative functional phenotypes. Fibroblast-instructive chemistries were identified, which we synthesized into surfactants to fabricate easy to administer microparticles for direct application to diabetic wounds. The pro-proliferative microfluidic derived particles were able to successfully promote neovascularisation, granulation tissue formation and wound closure after a single application to the wound bed. The data within this collection is associated with in vitro and in vivo assays carried out within the manuscript. | en_UK |
dc.language.iso | en_US | en_UK |
dc.publisher | The University of Nottingham | en_UK |
dc.rights | CC-BY | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.lcsh | Wound healing | en_UK |
dc.subject.lcsh | Fibroblasts | en_UK |
dc.subject.lcsh | Surface active agents | en_UK |
dc.title | Microparticles decorated with cell-instructive surface chemistries actively promote wound healing | en_UK |
dc.title.alternative | Wound healing microparticles | en_UK |
dc.identifier.doi | http://doi.org/10.17639/nott.7253 | |
dc.subject.free | cell-instructive surface chemistries, fibroblast modulation, microparticle production, wound healing, surfactants | en_UK |
dc.subject.jacs | Subjects Allied to Medicine::Medical technology::Medical technology not elsewhere classified | en_UK |
dc.subject.lc | R Medicine::R Medicine (General)::R855 Medical technology. Biomedical engineering. Electronics | en_UK |
dc.contributor.corporate | CicaBiomedical | en_UK |
uon.division | University of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Life Sciences | en_UK |
uon.funder.controlled | Engineering & Physical Sciences Research Council | en_UK |
uon.datatype | Raw data for laboratory based experiments | en_UK |
uon.grant | EP/N006615/1 | en_UK |
uon.collectionmethod | Data collection protocol | en_UK |
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