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dc.contributor.authorNguyen-Van-Tam, Jonathan S.
dc.coverage.spatialUK volunteersen_UK
dc.date.accessioned2020-05-14T07:36:49Z
dc.date.available2020-05-14T07:36:49Z
dc.date.issued2020-05-14
dc.identifier.urihttps://rdmc.nottingham.ac.uk/handle/internal/8311
dc.description.abstractUncertainty about the importance of influenza transmission by airborne droplet nuclei generates controversy for infection control. Human challenge-transmission studies have been supported as the most promising approach to fill this knowledge gap. Healthy, seronegative volunteer ‘Donors’ (n=52) were randomly selected for intranasal challenge with influenza A/Wisconsin/67/2005 (H3N2). ‘Recipients’ randomized to Intervention (IR, n=40) or Control (CR, n=35) groups were exposed to Donors for four days. IRs wore face shields and hand sanitized frequently to limit large droplet and contact transmission. One transmitted infection was confirmed by serology in a CR, yielding a secondary attack rate of 2.9% among CR, 0% in IR (p=0.47 for group difference), and 1.3% overall, significantly less than 16% (p<0.001) expected based on a proof-of-concept study secondary attack rate and considering that there were twice as many Donors and days of exposure. The main difference between these studies was mechanical building ventilation in the follow-on study, suggesting a possible role for aerosols.en_UK
dc.language.isoenen_UK
dc.publisherThe University of Nottinghamen_UK
dc.rightsCC-BY-NC*
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.lcshInfluenza -- Transmissionen_UK
dc.subject.lcshInfluenza -- Epidemiologyen_UK
dc.subject.meshInfluenza -- transmissionen_UK
dc.titleEvaluating Modes of Influenza Transmission (EMIT) data filesen_UK
dc.identifier.doihttp://doi.org/10.17639/nott.7051
dc.subject.freeInfluenza Transmission Human Challenge Studyen_UK
dc.subject.jacsMedicine and Dentistry::Clinical medicineen_UK
dc.subject.lcR Medicine::RA Public aspects of medicine::RA 421 Public health. Hygiene. Preventive Medicineen_UK
dc.contributor.corporateH-Vivo plc.en_UK
dc.date.collectionMarch to June 2013en_UK
uon.divisionUniversity of Nottingham, UK Campusen_UK
uon.divisionUniversity of Nottingham, UK Campus::Faculty of Medicine and Health Sciencesen_UK
uon.divisionUniversity of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Medicineen_UK
uon.funder.controlledOtheren_UK
uon.datatypeProtocol, Data files, and analysis filesen_UK
uon.funder.freeUS CDCen_UK
uon.grant1U01P000497-01en_UK
uon.collectionmethodProtocol for human challenge studyen_UK
uon.legalwritten informed consent from healthy volunteers in accordance with the principles of the Declaration of Helsinki, in compliance with UK regulatory and ethical (IRB) requirements, and registered with ClinicalTrials.gov (number NCT01710111)en_UK
uon.rightscontactThe University of Nottinghamen_UK
uon.identifier.risprojectRK0816en_UK


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