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dc.contributor.authorVedhara, Kavita
dc.date.accessioned2020-01-17T08:37:46Z
dc.date.available2020-01-17T08:37:46Z
dc.date.issued2020-01-17
dc.identifier.urihttps://rdmc.nottingham.ac.uk/handle/internal/8190
dc.description.abstractPsychological and behavioural factors influence the effectiveness of vaccines. This has led to interest in the potential for non-pharmacological treatments, which modify these factors, to enhance vaccine effectiveness. We conducted a systematic review and network meta-analysis (NMA) to examine the effects of non-pharmacological adjuvants on vaccine effectiveness, as measured by antibody responses to vaccination. Electronic databases (EMBASE, Medline, PsychINFO, CINAHL) were searched from inception to 6th February 2018. This yielded 100 eligible papers, reporting 106 trials: 79 interventions associated with diet and/or nutrition; 12 physical activity interventions and 9 psychological interventions. We observed that over half of all trials (k=58/106 trials) reported evidence of non-pharmacological interventions enhancing the antibody response to vaccination across one or more outcomes. The NMA considered the evidence for the effects of all intervention types compared with placebo on antibody titres (k=48 studies), seroconversion (k=25 studies) and seroprotection (k=23 studies) separately. The NMA provided weak evidence in support of nutritional formulae and probiotics in increasing antibody titres. This literature provides early evidence of nutritional formulae and probiotic interventions being associated with enhanced antibody responses to vaccination. The absence of evidence for other treatments is likely to be the consequence of limited and unreliable evidence on these treatments.en_UK
dc.language.isoenen_UK
dc.publisherThe University of Nottinghamen_UK
dc.rightsCC-BY-NC-ND*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.lcshVaccinesen_UK
dc.subject.lcshImmunoglobulinsen_UK
dc.titleVaccine NMA data & syntaxen_UK
dc.identifier.doihttp://doi.org/10.17639/nott.7032
dc.subject.freevaccinations; antibodies; diet; stress; physical activity; psychological interventionsen_UK
dc.subject.jacsSubjects Allied to Medicine::Pharmacology, toxicology & pharmacyen_UK
dc.subject.lcQ Science::QR Microbiology::QR180 Immunologyen_UK
uon.divisionUniversity of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Medicineen_UK
uon.funder.controlledOtheren_UK
uon.datatypeData extracted from primary research articles for network meta analysisen_UK
uon.funder.freeN/Aen_UK
uon.collectionmethodN/Aen_UK
uon.preservation.rarelyaccessedtrue


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CC-BY-NC-ND
Except where otherwise noted, this item's license is described as Creative Commons by Attribution, Non Commercial, No Derivatives