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dc.contributor.authorStolnik, Snow
dc.contributor.authorMantovani, Giuseppe
dc.contributor.otherLi, Huitong (Lucy)
dc.contributor.otherNieto-Orellana, Alejandro
dc.coverage.spatialUKen_UK
dc.coverage.spatialBelgiumen_UK
dc.date.accessioned2019-09-04T10:46:01Z
dc.date.available2019-09-04T10:46:01Z
dc.date.issued2019-09-04
dc.identifier.urihttps://rdmc.nottingham.ac.uk/handle/internal/7018
dc.description.abstractIn this study, we designed novel vitamin B12-targeted PEG-poly(GA) copolymers, and evaluated the role of B12-receptor mediated transport in increased cellular internalization in differentiated, polarized Calu-3 cells epithelial model. The formulations generated showed no significant toxicity or lung inflammation following chronic treatment. Taken together the results presented in this study show that vitamin B12 targeted PEG-poly(glutamic acid) copolymers are a potential as a new class of targeted ‘excipients’ for inhalation delivery of protein drugs to the lungs. Data presented here includes: Real-time polymerase chain reaction (qPCR); Flow cytometry (FACs); Transmission electron microscopy (TEM); Fluorescence Spectrophotometer; Confocal Microscopy.en_UK
dc.language.isoenen_UK
dc.publisherThe University of Nottinghamen_UK
dc.rightsCC-BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.lcshProtein drugsen_UK
dc.subject.lcshLungsen_UK
dc.subject.lcshCopolymersen_UK
dc.titleTargeted PEG-poly(glutamic acid) complexes for inhalation protein delivery to the lungen_UK
dc.identifier.doihttp://doi.org/10.17639/nott.7010
dc.subject.freePolymers, targeted, Vitamins, Lung, in vivo, proteinsen_UK
dc.subject.jacsSubjects Allied to Medicine::Pharmacology, toxicology & pharmacy::Pharmacologyen_UK
dc.subject.lcR Medicine::RS Pharmacy and materia medicaen_UK
dc.contributor.corporateVectura Group plcen_UK
dc.contributor.corporateUniversité libre de Bruxellesen_UK
uon.divisionUniversity of Nottingham, UK Campusen_UK
uon.funder.controlledOtheren_UK
uon.datatypeTEM images, Flow cytometry, qPCR data, Complement activation raw date, Confocal microscopyen_UK
uon.funder.freeVectura Group plcen_UK
uon.collectionmethodBeckman FC500Flow Cytometers, Prism, ImageJ, MoFlo Astrios Cell Sorter, Cary Eclipse Spectrophotometer, MicrosprayerTM model IA-1Cen_UK
uon.institutes-centresUniversity of Nottingham, UK Campusen_UK


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