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dc.contributor.authorPordea, Anca
dc.date.accessioned2024-03-27T16:48:54Z
dc.date.available2024-03-27T16:48:54Z
dc.date.issued2024-03-27
dc.identifier.urihttps://rdmc.nottingham.ac.uk/handle/internal/11380
dc.description.abstractIn this work, we investigate the encapsulation of a Cu(II)-phenanthroline complex (Cu(phen)(NO3)2) within HSAFt, as a potential vector for the delivery of anticancer agents. We immobilise Cu(II) within the protein as a metal complex with 1,10-phenanthroline, to form HSAFt-Cu(phen) dense particles that can be stored for months at low temperature (-20 °C). We subsequently characterise HSAFt-Cu(phen) by drug release studies and cytotoxicity assays against colorectal cancer cells and glioblastoma multiforme cells. We also investigate whether the presence of Cu(phen) inside HSAFt can offer additional benefits for the encapsulation and antitumour activity of anticancer drugs such as temozolomide (TMZ).en_UK
dc.language.isoenen_UK
dc.publisherThe University of Nottinghamen_UK
dc.rightsCC-BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.lcshDrug delivery systemsen_UK
dc.subject.lcshChemistryen_UK
dc.subject.lcshPharmacologyen_UK
dc.titleData for Encapsulation of copper phenanthroline within horse spleen apoferritin: characterisation, cytotoxic activity and ability to retain temozolomideen_UK
dc.identifier.doihttp://doi.org/10.17639/nott.7398
dc.subject.freeapoferritin, copper phenanthroline, drug encapsulationen_UK
dc.subject.jacsPhysical sciencesen_UK
dc.subject.jacsPhysical sciences::Chemistryen_UK
dc.subject.jacsSubjects Allied to Medicine::Pharmacology, toxicology & pharmacyen_UK
dc.subject.lcQ Scienceen_UK
dc.subject.lcR Medicine::RS Pharmacy and materia medicaen_UK
dc.subject.lcQ Science::QD Chemistryen_UK
dc.date.collection2019-2022en_UK
uon.divisionUniversity of Nottingham, UK Campusen_UK
uon.funder.controlledBiotechnology & biological Sciences Research Councilen_UK
uon.datatypeFiles for the characterisation of encapsulation experiments and of cytotoxic activityen_UK
uon.grantBB/M008770/1en_UK
uon.collectionmethodExperimental lab work and analytical methods for protein characterisation and bioactivityen_UK


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CC-BY
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