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dc.contributor.authorYue, Xing
dc.contributor.authorDorothee, Auer
dc.contributor.otherTayyib, Hayat
dc.contributor.otherStefan, Pszczolkowski
dc.contributor.otherPaul, Morgan
dc.contributor.otherJonathan, Evans
dc.contributor.otherChris, Tench
dc.description.abstractAccess to these files may be requested. Please contact Dr Xing at While NM-MRI has shown promise in diagnosing PD, its potential as a progression marker, particularly in the early stages when disease-modifying treatments are most effective, remains relatively unexplored. Our InsIghtPD study focuses on evaluating the substantia nigra, primarily looking at nigral depigmentation at baseline, 6- and 12-months’ follow-up. Secondary metrics, such as free water, kurtosis, and susceptibility, are also examined. Additionally, the study explores other whole brain metrics with potential as progression markers. The goal is to understand the minimal detectable change in these MRI metrics during the early clinical phase of PD. Furthermore, the study seeks to differentiate PD-related pathological changes from the effects of natural aging, which is critical for accurately assessing disease progression.en_UK
dc.publisherThe University of Nottinghamen_UK
dc.subject.lcshParkinson's disease – Imagingen_UK
dc.subject.lcshBrain – Imagingen_UK
dc.subject.lcshMagnetic resonance imagingen_UK
dc.subject.meshParkinson Diseaseen_UK
dc.subject.meshMagnetic Resonance Imaging – methodsen_UK
dc.titleSerial 3T MRI in early Parkinson’s to validate PD progression markers: Rationale and MRI analysis plan for nigral depigmentation at baseline, 6- and 12-months’ follow-upen_UK
dc.subject.freeNeuromelanin MRI, depigmentation rate, early Parkinson's disease, substantia nigra, disease progression, multimodal MRIen_UK
dc.subject.jacsSubjects Allied to Medicine::Medical technology::Radiology::Radiography, diagnosticen_UK
dc.subject.jacsSubjects Allied to Medicine::Anatomy, physiology & pathology::Neuroscienceen_UK
dc.subject.lcW Medicine and related subjects (NLM Classification)::WL Nervous systemen_UK
uon.divisionUniversity of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Medicineen_UK
uon.funder.freeWeston Brain Institute, Weston Family Foundationen_UK
uon.funder.freeNational Institute for Health Research, Nottingham Biomedical Research Centreen_UK
uon.collectionmethodData analysis planen_UK

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