Serial 3T MRI in early Parkinson’s to validate PD progression markers: Rationale and MRI analysis plan for nigral depigmentation at baseline, 6- and 12-months’ follow-up
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Publication date
2023-11-02Creators
Yue, Xing
Dorothee, Auer
Metadata
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Access to these files may be requested. Please contact Dr Xing at You.Xing@nottingham.ac.uk. While NM-MRI has shown promise in diagnosing PD, its potential as a progression marker, particularly in the early stages when disease-modifying treatments are most effective, remains relatively unexplored.
Our InsIghtPD study focuses on evaluating the substantia nigra, primarily looking at nigral depigmentation at baseline, 6- and 12-months’ follow-up. Secondary metrics, such as free water, kurtosis, and susceptibility, are also examined. Additionally, the study explores other whole brain metrics with potential as progression markers. The goal is to understand the minimal detectable change in these MRI metrics during the early clinical phase of PD. Furthermore, the study seeks to differentiate PD-related pathological changes from the effects of natural aging, which is critical for accurately assessing disease progression.
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Subjects
- Parkinson's disease – Imaging
- Brain – Imaging
- Magnetic resonance imaging
- Parkinson Disease
- Neuroimaging
- Magnetic Resonance Imaging – methods
- Neuromelanin MRI, depigmentation rate, early Parkinson's disease, substantia nigra, disease progression, multimodal MRI
- Subjects Allied to Medicine::Medical technology::Radiology::Radiography, diagnostic
- Subjects Allied to Medicine::Anatomy, physiology & pathology::Neuroscience
- W Medicine and related subjects (NLM Classification)::WL Nervous system
Divisions
- University of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Medicine
Deposit date
2023-11-02Data type
ProtocolContributors
- Tayyib, Hayat
- Stefan, Pszczolkowski
- Paul, Morgan
- Jonathan, Evans
- Chris, Tench
Funders
- Other
- Weston Brain Institute, Weston Family Foundation
- National Institute for Health Research, Nottingham Biomedical Research Centre
Grant number
- UB190188
Data collection method
Data analysis planResource languages
- en