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Immune-instructive polymers
(The University of Nottingham, 2020-05-01)
We identify polymers which instruct different immunological responses by modulating macrophage attachment and polarisation to pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotypes. These immune-instructive ...
Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation
(The University of Nottingham, 2020-05-05)
Material topography is known to influence macrophage attachment and phenotype, providing opportunities for the rational design of ‘immune-instructive’ topographies to modulate macrophage function and thus foreign body ...
Single cell metabolic profiling of macrophages using 3D OrbiSIMS: correlations with phenotype
(The University of Nottingham, 2022-06-10)
ABSTRACT: Macrophages are important immune cells that respond to environmental cues acquiring a range of activation status represented by pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes at each end of their ...