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In situ protein identification, mapping and depth profiling using 3D OrbiSIMS
(The University of Nottingham, 2020-08-28)
Label-free protein characterisation at surfaces requires digestion or matrix application prior to mass spectrometry. We report the assignment of undigested proteins at surfaces using secondary ion mass spectrometry (SIMS). ...
Spatially resolved molecular compositions of insoluble multi-layer deposits responsible for increased pollution from internal combustion engines
(The University of Nottingham, 2020-11-04)
Data required to recreate all figures including uncropped images for the article published in ACS Applied Materials and Interfaces:
- 3D OrbiSIMS data:
itmx. files of full depth profiles for all samples
itmx. files ...
Elucidating the molecular landscape of the stratum corneum
(The University of Nottingham, 2022-03-18)
• Characterization of the molecular structure of skin, especially the barrier layer, the stratum corneum using 3D OrbiSIMS.
• Understand the chemical variations relating to fundamental biological processes, such as the ...
Single cell metabolic profiling of macrophages using 3D OrbiSIMS: correlations with phenotype
(The University of Nottingham, 2022-06-10)
ABSTRACT: Macrophages are important immune cells that respond to environmental cues acquiring a range of activation status represented by pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes at each end of their ...
Molecular formula prediction for chemical filtering of 3D OrbiSIMS Datasets
(The University of Nottingham, 2022-02-08)
3D OrbiSIMS raw data required to reproduce figures in the manuscript linked to this repository. File formats are itm., enabling access to both spectral and depth profiling data for each series.
Secondary ion mass spectrometry analysis of pentosan polysulfate
(The University of Nottingham, 2023-04-30)
Pentosan polysulfate sodium (PPS) is a glycosaminoglycan mimetic that is the only current active pharmaceutical ingredient (API) for the oral treatment of interstitial cystitis. PPS is an inherently complex API due to ...
Time resolved growth of (N)-polycyclic aromatic hydrocarbons in engine deposits uncovered with OrbiSIMS depth profiling
(University of Nottingham, 2022-08-15)
Carbonaceous deposits are ubiquitous, being formed on surfaces in engines, fuel systems and on catalysts operating at high temperatures for hydrocarbon transformations. In internal combustion engines, their formation ...