An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 1520R-2 Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 1520R-2 (III) Source: NIG Name: WASp (2) Full name: WASp Also known as: Wsp, D-WASP, dWASP Annotation symbol: CG1520 FlyBase ID: FBgn0024273 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks) Included files: 220114_lgl_1520R2_An1_combined.tif 220114_lgl_1520R2_An2_combined.tif An10Lgl1520R2w.tif An1 Lgl 1520R2 w1.tif An1 Lgl 1520R2 w2.tif lgl1520R2Animal2.tif Lgl1520R2Animal3.tif