An in vivo systematic genetic analysis of tumour progression in Drosophila -
RNAi line: 6241

   Metastasis is the leading cause of death for cancer patients.
   Consequently it is imperative that we improve our understanding of the
   molecular mechanisms that underlie progression of tumour growth towards
   malignancy. Advances in genome characterisation technologies have been
   very successful in identifying commonly mutated or misregulated genes
   in a variety of human cancers. A major challenge however is the
   translation of these findings to new biological insight due to the
   difficulty in evaluating whether these candidate genes drive tumour
   progression. Using the genetic amenability of Drosophila melanogaster
   we generated tumours with specific genotypes in the living animal and
   carried out a detailed systematic loss-of-function analysis to identify
   numerous conserved genes that enhance or suppress epithelial tumour
   progression. This enabled the discovery of functional cooperative
   regulators of invasion and the establishment of a network of conserved
   ‘invasion suppressors’.

   RNAi line: 6241 (III)
   Source: VDRC
   Name: vav (1)
   Full name: Vav guanine nucleotide exchange factor
   Also known as: DroVav
   Annotation symbol: CG7893
   FlyBase ID: FBgn0040068
   File naming convention: File names typically contain representations of
   date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to
   accommodate larger samples that require multiple image stacks)

   Included files: An1 6241 w1 240816.tif An1 6241 w2 240816.tif An2 6241
   240816.tif An4 6241 180816.tif An5 6241 240816.tif lgl6241An4w1
   190816.tif lgl6241An4w2 190816.tif