An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 6241

Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.

RNAi line: 6241 (III)
Source: VDRC

Name: vav (1)
Full name: Vav guanine nucleotide exchange factor
Also known as: DroVav
Annotation symbol: CG7893
FlyBase ID: FBgn0040068

File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)

Included files: An1 6241 w1 240816.tif An1 6241 w2 240816.tif An2 6241 240816.tif An4 6241 180816.tif An5 6241 240816.tif lgl6241An4w1 190816.tif lgl6241An4w2 190816.tif