Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.
RNAi line: 29413 (III)
Source: VDRC
Name: Unc-89 (2)
Full name: Unc-89
Also known as: unc89, BEST:HL01080 , obs
Annotation symbol: CG33519
FlyBase ID: FBgn0053519
File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
Included files: 020414_Lgl29413An12w1_combined.tif 020414_Lgl29413An12w2_combined.tif 020414_Lgl29413An13_combined.tif 030414.lei - Lgl29913An12.tif 030614_Lgl29413An2_combined.tif 040414_lgl_29413_Animal10_combined.tif 040414_lgl_29413_Animal11_combined.tif 040614_Lgl29413An3_combined.tif