Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.
RNAi line: 31456 (X)
Source: VDRC
Name: TTLL3B
Full name: Tubulin tyrosine ligase-like 3B
Also known as:
Annotation symbol: CG11201
FlyBase ID: FBgn0031853
File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
Included files: 020316_Screen_An40_31456_w_combined.tif 040316_An36_31456_w_combined.tif 080316_An38_31456_w_combined.tif 090316_An11_31456(X)_w_combined.tif 260216_An4_31456_w1_combined.tif 260216_An4_31456_w2_combined.tif