An in vivo systematic genetic analysis of tumour progression in Drosophila -
RNAi line: 34836

   Metastasis is the leading cause of death for cancer patients.
   Consequently it is imperative that we improve our understanding of the
   molecular mechanisms that underlie progression of tumour growth towards
   malignancy. Advances in genome characterisation technologies have been
   very successful in identifying commonly mutated or misregulated genes
   in a variety of human cancers. A major challenge however is the
   translation of these findings to new biological insight due to the
   difficulty in evaluating whether these candidate genes drive tumour
   progression. Using the genetic amenability of Drosophila melanogaster
   we generated tumours with specific genotypes in the living animal and
   carried out a detailed systematic loss-of-function analysis to identify
   numerous conserved genes that enhance or suppress epithelial tumour
   progression. This enabled the discovery of functional cooperative
   regulators of invasion and the establishment of a network of conserved
   ‘invasion suppressors’.

   RNAi line: 34836 (III)
   Source: VDRC
   Name: Traf-like
   Full name: TNF-receptor-associated factor-like
   Also known as: Traf3, dTRAF3
   Annotation symbol: CG4394
   FlyBase ID: FBgn0030748
   File naming convention: File names typically contain representations of
   date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to
   accommodate larger samples that require multiple image stacks)

   Included files: 041214_An15_34836_w_combined.tif
   270115_Lgl34836An1_combined.tif 280115_An3_34836_w_combined.tif
   290115_Lgl34836An1w1_combined.tif 290115_Lgl34836An1w2_combined.tif
   290115_Lgl34836An2_combined.tif