An in vivo systematic genetic analysis of tumour progression in Drosophila -
RNAi line: 14026R-1

   Metastasis is the leading cause of death for cancer patients.
   Consequently it is imperative that we improve our understanding of the
   molecular mechanisms that underlie progression of tumour growth towards
   malignancy. Advances in genome characterisation technologies have been
   very successful in identifying commonly mutated or misregulated genes
   in a variety of human cancers. A major challenge however is the
   translation of these findings to new biological insight due to the
   difficulty in evaluating whether these candidate genes drive tumour
   progression. Using the genetic amenability of Drosophila melanogaster
   we generated tumours with specific genotypes in the living animal and
   carried out a detailed systematic loss-of-function analysis to identify
   numerous conserved genes that enhance or suppress epithelial tumour
   progression. This enabled the discovery of functional cooperative
   regulators of invasion and the establishment of a network of conserved
   ‘invasion suppressors’.

   RNAi line: 14026R-1 (III)
   Source: NIG
   Name: tkv (1)
   Full name: thickveins
   Also known as: str, Brk25D, dtfr, l(2)04415
   Annotation symbol: CG14026
   FlyBase ID: FBgn0003716
   File naming convention: File names typically contain representations of
   date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to
   accommodate larger samples that require multiple image stacks)

   Included files: 030913_Lgl14026R1An4w1_combined.tif
   030913_Lgl14026R1An4w2_combined.tif
   040913_An10_Lgl_14026R1_w1_combined.tif
   040913_An10_Lgl_14026R1_w2_combined.tif
   050913_14026R1_A3_W1_combined.tif 050913_14026R1_A5_W1_combined.tif
   160713_Lgl14026R1An1w1_combined.tif 180215_Lgl14026R1An3_combined.tif
   190215_An5_14026r1_w_combined.tif 200613_lgl_14026r1_an2__combined.tif
   241014_lgl_14026R1_An1_combined.tif 250613_Lgl14026R1An6w1_combined.tif
   250713_An1_Lgl_14026R1_w__combined.tif
   250713b_An1_Lgl_14026R1_w__combined.tif
   260613_An13_Lgl_14026R1_w_combined.tif
   291014_Lgl14026R1An7w1_combined.tif 291014_Lgl14026R1An7w2_combined.tif
   311014_Lgl14026R1_An5_combined.tif