Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.
RNAi line: 6281R-2 (III)
Full name: Tissue inhibitor of metalloproteases
Also known as:
Annotation symbol: CG6281
FlyBase ID: FBgn0025879
File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
Included files: 030713_Lgl6281R2An7w1_combined.tif 040713_lgl_6281r2_a10_w1_combined.tif 040713_lgl_6281r2_a11_w1_combined.tif 040713_lgl_6281r2_a11_w2_combined.tif 100713_6281R2_A5_w1_combined.tif 100713_6281R2_A5_w2_combined.tif 120613_An3_Lgl_6281R2_w1_combined.tif 120613_An3_Lgl_6281R2_w2_combined.tif 120613_An4_Lgl_6281R2_w1_combined.tif 120613_An4_Lgl_6281R2_w2_combined.tif 120613_An5_Lgl_6281R2_w1_combined.tif 170713_An8_Lgl_6281R2_w1_combined.tif 170713_An8_Lgl_6281R2_w2_combined.tif 190613_An1_Lgl_6281R2_w_combined.tif 190613_An6_Lgl_6281R2_w1_combined.tif 190613_An6_Lgl_6281R2_w2_combined.tif 190613_An6_Lgl_6281R2_w3_combined.tif