An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 33415

Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.

RNAi line: 33415 (III)
Source: Bloomington

Name: ss (2)
Full name: spineless
Also known as:
Annotation symbol: CG6993
FlyBase ID: FBgn0003513

File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)

Included files: 200116_An20_33415_w1_combined.tif 200116_An20_33415_w2_combined.tif 210616_An1_33415_w_combined.tif 220116_An8_33415_w__combined.tif 260116_An2_33415_w_combined.tif An26 33415 w.tif