An in vivo systematic genetic analysis of tumour progression in Drosophila -
RNAi line: 6532

   Metastasis is the leading cause of death for cancer patients.
   Consequently it is imperative that we improve our understanding of the
   molecular mechanisms that underlie progression of tumour growth towards
   malignancy. Advances in genome characterisation technologies have been
   very successful in identifying commonly mutated or misregulated genes
   in a variety of human cancers. A major challenge however is the
   translation of these findings to new biological insight due to the
   difficulty in evaluating whether these candidate genes drive tumour
   progression. Using the genetic amenability of Drosophila melanogaster
   we generated tumours with specific genotypes in the living animal and
   carried out a detailed systematic loss-of-function analysis to identify
   numerous conserved genes that enhance or suppress epithelial tumour
   progression. This enabled the discovery of functional cooperative
   regulators of invasion and the establishment of a network of conserved
   ‘invasion suppressors’.

   RNAi line: 6532 (III)
   Source: VDRC
   Name: SMC1
   Full name: Structural maintenance of chromosomes 1
   Also known as: DmSMC1
   Annotation symbol: CG6057
   FlyBase ID: FBgn0040283
   File naming convention: File names typically contain representations of
   date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to
   accommodate larger samples that require multiple image stacks)

   Included files: 041214_An3_6532_w_combined.tif
   101214b_Lgl6532An18_combined.tif 121214_lgl_6532_An12_combined.tif
   181214_lgl_6532_An10_combined.tif 21114_An6_6532_w_combined.tif
   21114.lei - An6 6532 w.tif 281114_An6_6532_w_combined.tif