An in vivo systematic genetic analysis of tumour progression in Drosophila -
RNAi line: 10696

   Metastasis is the leading cause of death for cancer patients.
   Consequently it is imperative that we improve our understanding of the
   molecular mechanisms that underlie progression of tumour growth towards
   malignancy. Advances in genome characterisation technologies have been
   very successful in identifying commonly mutated or misregulated genes
   in a variety of human cancers. A major challenge however is the
   translation of these findings to new biological insight due to the
   difficulty in evaluating whether these candidate genes drive tumour
   progression. Using the genetic amenability of Drosophila melanogaster
   we generated tumours with specific genotypes in the living animal and
   carried out a detailed systematic loss-of-function analysis to identify
   numerous conserved genes that enhance or suppress epithelial tumour
   progression. This enabled the discovery of functional cooperative
   regulators of invasion and the establishment of a network of conserved
   ‘invasion suppressors’.

   RNAi line: 10696 (III)
   Source: VDRC
   Name: Rbf1
   Full name: Retinoblastoma-family protein
   Also known as: Rbf, Rb, EG:34F3 .3, dRBF, pRb
   Annotation symbol: CG7413
   FlyBase ID: FBgn0015799
   File naming convention: File names typically contain representations of
   date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to
   accommodate larger samples that require multiple image stacks)

   Included files: 020713_An10_Lgl_10696_w_combined.tif
   180613_Lgl10696An1w1_combined.tif 180613_Lgl10696An1w2_combined.tif
   180613_Lgl10696An6w1_combined.tif 190613_An5_Lgl_10696_w_combined.tif
   200813_10696_A1_W1_combined.tif 200813_10696_A2_W1_combined.tif
   200813_10696_A8_W1_combined.tif 250613_Lgl10696An1w1_combined.tif
   250613_Lgl10696An1w2_combined.tif 260613_An8_Lgl_10696_w_combined.tif