Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.
RNAi line: 10696 (III)
Full name: Retinoblastoma-family protein
Also known as: Rbf, Rb, EG:34F3 .3, dRBF, pRb
Annotation symbol: CG7413
FlyBase ID: FBgn0015799
File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
Included files: 020713_An10_Lgl_10696_w_combined.tif 180613_Lgl10696An1w1_combined.tif 180613_Lgl10696An1w2_combined.tif 180613_Lgl10696An6w1_combined.tif 190613_An5_Lgl_10696_w_combined.tif 200813_10696_A1_W1_combined.tif 200813_10696_A2_W1_combined.tif 200813_10696_A8_W1_combined.tif 250613_Lgl10696An1w1_combined.tif 250613_Lgl10696An1w2_combined.tif 260613_An8_Lgl_10696_w_combined.tif