An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 35731 Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 35731 (III) Source: VDRC Name: pTEN (1) Full name: Phosphatase and tensin homolog Also known as: dPTEN Annotation symbol: CG5671 FlyBase ID: FBgn0026379 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks) Included files: 030913_Lgl35731An7w1_combined.tif 040713_lgl_35731_a5_w1_combined.tif 040713_lgl_35731_a6_w1_combined.tif 040713_lgl_35731_a7_w1_combined.tif 190713_Lgl35731An5w1_combined.tif 220813_Lgl35731An7w1_combined.tif 280813_35731_A7_W1_combined.tif