Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.
RNAi line: 31690 (III)
Source: VDRC
Name: PpV
Full name: Protein phosphatase V
Also known as:
Annotation symbol: CG12217
FlyBase ID: FBgn0003139
File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
Included files: 040315b_Lgl31690An9w1_combined.tif 040315b_Lgl31690An9w2_combined.tif 050315_An4_31690_w_combined.tif 190515.lei - An1 31610 w.tif 190515.lei - An2 31610 w.tif 260215_lgl_31690_An6_combined.tif 270315_lgl_31690_An3_combined.tif