Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.
RNAi line: 33933 (III)
Full name: karst
Also known as: βH, βH-Spectrin, βH-Spec, βHeavyspectrin
Annotation symbol: CG12008
FlyBase ID: FBgn0004167
File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
Included files: 090216_An43_33933_w_combined.tif 100216_An19_33933_w_combined.tif 110216_An21_33933_w_combined.tif 110216_An22_33933_w_combined.tif 120216_An20_33933_w_combined.tif