Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.
RNAi line: 30806 (III)
Full name: Ajuba LIM protein
Also known as: djub
Annotation symbol: CG11063
FlyBase ID: FBgn0030530
File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
Included files: 021014_An7_30806_w_combined.tif 031014_lgl_30806_An6_combined.tif 031014_lgl_30806_An7_combined.tif 260914_lgl_30806_An8_combined.tif 300914_Lgl30806An9_combined.tif x_021014_An7_30806_w_combined.tif x_031014_lgl_30806_An6_combined.tif x_031014_lgl_30806_An7_combined.tif x_260914_lgl_30806_An8_combined.tif