Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.
RNAi line: 15302 (III)
Full name: Elongin C
Also known as: EloC
Annotation symbol: CG9291
FlyBase ID: FBgn0266711
File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
Included files: 171014.lei - lgl 15502 An5.tif 211014_Lgl15302An12w1_combined.tif 211014_Lgl15302An12w2_combined.tif 241014.lei - lgl 15502 An8.tif 241014.lei - lgl 15502 An9.tif An5 15302 w2.tif