An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 29424

Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.

RNAi line: 29424 (III)
Source: VDRC

Name: CG32238 (2)
Full name: Tubulin tyrosine ligase-like 1B
Also known as: TTLL1B
Annotation symbol: CG32238
FlyBase ID: FBgn0052238

File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)

Included files: 050215_An3_29424_w_combined.tif 100215_An4_29424_w_combined.tif 120215_An4_29424_w_combined.tif 121214.lei - lgl 29429 An5.tif 171214.lei - Lgl29429An7w2.tif