An in vivo systematic genetic analysis of tumour progression in Drosophila -
RNAi line: 8203R-3

   Metastasis is the leading cause of death for cancer patients.
   Consequently it is imperative that we improve our understanding of the
   molecular mechanisms that underlie progression of tumour growth towards
   malignancy. Advances in genome characterisation technologies have been
   very successful in identifying commonly mutated or misregulated genes
   in a variety of human cancers. A major challenge however is the
   translation of these findings to new biological insight due to the
   difficulty in evaluating whether these candidate genes drive tumour
   progression. Using the genetic amenability of Drosophila melanogaster
   we generated tumours with specific genotypes in the living animal and
   carried out a detailed systematic loss-of-function analysis to identify
   numerous conserved genes that enhance or suppress epithelial tumour
   progression. This enabled the discovery of functional cooperative
   regulators of invasion and the establishment of a network of conserved
   ‘invasion suppressors’.

   RNAi line: 8203R-3 (III)
   Source: NIG
   Name: CDK5
   Full name: Cyclin-dependent kinase 5
   Also known as:
   Annotation symbol: CG8203
   FlyBase ID: FBgn0013762
   File naming convention: File names typically contain representations of
   date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to
   accommodate larger samples that require multiple image stacks)

   Included files: 130913_Lgl8203R3An2w1_combined.tif
   130913_Lgl8203R3An2w2_combined.tif 130913_Lgl8203R3An3w1_combined.tif
   130913_Lgl8203R3An3w2_combined.tif 130913_Lgl8203R3An4w1_combined.tif
   130913_Lgl8203R3An4w2_combined.tif 190713_Lgl8203R3An6w1_combined.tif
   230713_Lgl8203R3An3w1_combined.tif 230713_Lgl8203R3An3w2_combined.tif
   230713_Lgl8203R3An7w1_combined.tif 230713_Lgl8203R3An7w2_combined.tif
   230713_Lgl8203R3An8w1_combined.tif 250613_Lgl8203R3An7w1_combined.tif
   250613_Lgl8203R3An7w2_combined.tif 260613_An5_Lgl_8203R3_w_combined.tif
   260613_An6_Lgl_8203R3_w1_combined.tif
   260613_An6_Lgl_8203R3_w2_combined.tif