Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’.
RNAi line: 15010R-3 (III)
Full name: archipelago
Also known as:
Annotation symbol: CG15010
FlyBase ID: FBgn0041171
File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
Included files: ago_An1_160914.lei - Lgl15010R3 An4.tif ago_An2_170914.lei - lgl 15010R3 An10.tif ago_an4_190914.lei - lgl 15010R3 An8.tif ago_An4_221013.lei - Lgl15010R3An2w1.tif ago_An5A_230914.lei - Lgl15010R3 An1w1.tif ago_An5B_230914.lei - Lgl15010R3 An1w2.tif ago_An6_240914.lei - Lgl15010R3An1.tif